Bones are one important part of your body. Their are number of problems one can face with the bones on such problem is Osteoporosis which implies permeable bones, is a dynamic condition wherein bones become basically powerless and are bound to crack or break. It is once in a while called a "quiet" malady, since bone misfortune regularly happens without you knowing it. Typically, the body shapes enough new bone tissue to adjust the measure of bone tissue separated and consumed by the body. This is a characteristic procedure called bone turnover. All through the early piece of your life, the measure of bone lost and the measure of bone picked up stay adjusted. Bone mass (size and thickness) increments during youth and early grown-up life, arriving at its most extreme by the age of 20 to 25. After midlife, more bone is separated than is framed, and bone mass gradually decays.
No matter which osteoporosis drugs your doctor chooses for you, it’s helpful to know as much as possible about how the disease has affected you. One type to tell is to ask about your “markers”.
What a difference a decade makes. In 1995, Fosamax, the mediation in a class of drugs called Bisphosphonates, came on the market. Bisphosphonates affect what’s called the bone remodeling cycle, which involves bone Resorption (the dissolving to existing bone tissue) and formation (the filling of the resulting small cavities with new bone tissue). Commonly, these two parts of the cycle are balanced, but when resorption outpaces formation, you eventually have osteoporosis. By slowing stopping the bone Resorbing portion of the remodeling cycle, Bisphosphonates allow new bone formation to catch up with bone Resorption. Fosamax and other drugs such as Actonel, Boniva, and Reclast increase bone density and help prevent and treat osteoporosis and/or reduce the risk fractures.
Increasing the bone density:-Over three years on Fosamax, you can expect a 6% to 8% in spinal bone density and a 4% to 6% increase in hip bone density, ‘Michael Holick, MD,PhD, a professor of medicine, physiology, and biophysics at Bostaon university medical center. “And the Bisphosphonates have been found to decreased spinal fracture by as much as 70% over three years. An hip fractures by as much as 50%.” Recently completed studies show that these effects continue with long-term use. “you see the most dramatic effect in the effect in the first three to five years on the medications, but we continue to see a smaller but significant improvement in bone density for up to 12 years, “Holick says, “more important, if you stop consume the drugs, you begin to lose bone density at the same rate you would have before.” But Bisphosphonates do have some limitations. For one thing, the regimen for taking them effectively is much intense. Since as little as 1% to 5% of the drug is absorbed by your body the rest is excreted you have to make sure to make the most of every dose. With drugs like Fosamax and Actonel, this means taking it first thing in the morning once a week and the not ingesting anything else for half an hour to an hour. “you have to stay upright for 30 to 50 minutes, and if you even brush your teeth, drink coffee, or juice, or take a nasal spray or mouthwash, it may affect the absorption rate of density, “say Rober recker, MD, professor of medicine and director of the osteoporosis research center at Creighton university school of medicine in Omaha, neb. “you take the tablets with 5 ounces of water, and then nothing more for up to an hour. I was astonished at how many people find that very difficult.” In a less percentage of patients, Bisphosphonates can also cause some gastrointestinal disease. “Some persons do have GI complaints, “say Holick. “it is a very small number, but a few people just cannot tolerate it. Reclast is also a Bishphosphonate. However this treatment is given intravenously, so it bypasses the gastrointestinal tract. Treatment is given once a year.
For those patients, another option/way is Evista (Raloxifene), one of a class of medicines known as selective estrogen receptor modulators, or SERMs, formulate to offer some of the benefits of estrogens without their potential disadvantage (such as increased breast cancer risk). It is hard to compare the data directly, but while it is effective in maintaining bone density, I tend to Bisphosphonates, “says Recker. But if a patient has difficulty taking Bisphosphonates because of gastrointestinal problems perhaps if she is only at risk for osteoporosis, a condition known as osteopenia evista may be a good option. “I tend to use it in younger women, in their 50 or early 60s, who have Osteopenia and show markers of increased bone Resorption, “say Holick. They may not need to increase bone density, but rather just keep what they have got”. One other option: hormone replacement therapy, or HRT. This is not generally used as front line osteoporosis therapy these days, though. Rather, its bone density benefits are often and add-on benefit for women who take HRT to cope with menopausal symptoms. HRTs are used much less in present year, and always with caution, because of physician showing that they can increase the risk of blood clots (so can Evista), heart attack and stroke, and breast cancer. Fortical and miacalcin involve the active ingredient Calcitonin, which is a naturally producing hormone that inhibits bone loss. It is also comes as a nasal spray or injection. Undesirable side effects include nausea and skin rashes. Prolia is a treatment approved for the diagnosed of osteoporosis in postmenopausal women who are at high risk for fracture. Prolia is a so called monoclonal antibody a fully human, lab produced antibody that inactivates the body’s bone breakdown mechanism. It is the first “biologic therapy” to be approved for treatment of osteoporosis. It is given by injection twice or thrice a year. The most common side effects seen in patients taking Prolia are back pain, pain in the extremities, muscle and bone pain, headache, high cholesterol levels, and urinary bladder infections etc. The medicines also appear to lower calcium levels. Patients with low blood calcium levels should not consume Prolia until the condition is corrected.
When you are being treated for osteoporosis, your doctor orders a blood or urine test. This reveals several markers levels of different enzymes, proteins, and other substances circulating in the body that provide clues about your disease and the progress of your treatment. Some of the bone markers that your physician may order involve - alkaline phosphates, bone specific alkaline Phosphatase (BALP), and serum or urine NTX etc. These are mainly used to help determine bone turnover.
Some Of These Measures Include:-
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