How Long Does Amoxicillin Stay in Your System?

How Long Does Amoxicillin Stay in Your System?
Published : Jun 01, 2024

When you take antibiotics to treat a bacterial infection, the medication stays in your body for hours and even days. Amoxicillin, a popular penicillin antibiotic, is prescribed to treat various types of bacterial infections in both adults and children. It is effective against strep throat, skin infections, urinary tract infections, tooth infections, and other bacterial infections. 

However, when you start taking a new medicine, it is natural to wonder how long it will stay in your system and how long it will take to make you feel better. 

How long does Amoxicillin stay in your system? 

Most antibiotics can begin to work right after you take the first dosage. It is essential to know that each antibiotic can stay in your body for a different amount of time because several other classes exist. 

Some factors can influence how long an antibiotic stays in your system, such as the type of antibiotic you take, how long you are taking it, and your health.

Amoxicillin can stay in your system for 12 hours after your last dose. However, the exact time will depend on factors like the patient’s body weight and the dose administered. Other factors, such as kidney health or interacting medicines, also play roles.  

After taking an Amoxicillin dose, it excretes through the urine and kidneys. Most of it is expected to pass through urine within eight hours of your last dosage and entirely by 12 hours. 

You need to understand that the time it takes for Amoxicillin to completely leave the body is going to be different for everyone. Newborns and people with kidney disorders might clear Amoxicillin slowly, while other patients can take a few days to clear this penicillin antibiotic.

How long does Amoxicillin take to work? 

Amoxicillin is considered a fast-acting antibiotic that starts working right after you take a dose and reaches its full effectiveness within an hour or two. However, this medicine will not relieve the symptoms of your infection immediately. Most people start to feel better within 72 hours after taking Amoxicillin, while others notice improvements within 24 to 48 hours. 

Taking antibiotics too often can cause bacteria in your body to develop more resistance to the medicines. Inform the doctor if you find that antibiotics do not work as intended.

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How long do you have to take Amoxicillin? 

In most conditions, doctors prescribe a course of Amoxicillin for 5 to 10 days. Depending on the type of infection and how severe it is, this antibiotic medication can also be prescribed for 14 days. 

Even if you start feeling better after a few days of taking Amoxicillin, make sure you finish the complete treatment. If you don’t, your body can have some leftover bacteria that can become resistant to antibiotics, making it hard to treat future infections. 

What is the right time to take an Amoxicillin tablet? 

Doctors prescribe Amoxicillin two or three times a day for most adults and children. However, to get the most benefits, patients are suggested to take it at mealtimes. 

It is better to take Amoxicillin with food to avoid common side effects of this antibiotic, like vomiting, nausea, and diarrhea. To reduce stomach-related side effects, take Amoxicillin with food. This way, you will also remember to take this medicine daily without skipping doses.


Amoxicillin plays a vital role in treating bacterial infections. It stays in the system for 12 long hours for some people. Also, it is safe to take Amoxicillin under a doctor’s supervision. You can manage the side effects quickly, and common side effects go away as your body adjusts to Amoxicillin.

Therefore, how long you need to continue the treatment with Amoxicillin will depend on severity and type of infection.